Neutrophil chemotaxis in patients with burns.

Annals of surgery ·Vol. 186 ·No. 6 ·1977-12-00 ·Pages 746-8

Fikrig SM, Karl SC, Suntharalingam K

Abstract

In a group of 22 patients with second and third degree burns, seven were found to have impaired chemotaxis. The chemotactic defect was present from two to 68 days and eventually became normal. The impairment was found to be due to a primary transient defect in polymorphonuclear leukocytes and not to an inhibitor or inactivator in the serum.

MeSH Terms

Adolescent Adult Aged Burns/blood,microbiology,physiopathology Chemotaxis, Leukocyte Child Female Humans Male Middle Aged Neutrophils/physiology Nitroblue Tetrazolium Shock, Traumatic/physiopathology

Chemicals

Nitroblue Tetrazolium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fikrig S M

Karl S C

Suntharalingam K

References (11)

11 references, click to expand

THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.
J Exp Med. 1965 Aug 1;122:327-46 PMID: 14316948
SEPARATION OF WHITE BLOOD CELLS.
Nature. 1964 Nov 21;204:793-4 PMID: 14235685
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.
J Exp Med. 1962 Mar 1;115:453-66 PMID: 13872176
The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes.
J Biol Chem. 1959 Jun;234(6):1355-62 PMID: 13654378
Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid.
Lancet. 1968 Sep 7;2(7567):532-4 PMID: 4175397
Leukoegresin: a factor from rabbit skin associated with leucocytic emigration in the Arthus reaction.
Nature. 1968 Jun 8;218(5145):977-8 PMID: 4234575
Disorders of neutrophil function. Defects in the early stages of the phagocytic process.
Clin Exp Immunol. 1973 Jan;13(1):21-8 PMID: 4587499
Burn sepsis and burn toxin.
Ann R Coll Surg Engl. 1974 Nov;55(5):226-35 PMID: 4429330
Evaluation of leukocyte chemotaxis in vitro in thermally injured patients.
J Clin Invest. 1974 Oct;54(4):1001-4 PMID: 4430710
Neutrophil function in selected surgical disorders.
Ann Surg. 1968 Sep;168(3):447-58 PMID: 4877591
Neutrophil dysfunction and sepsis in burn injury.
Surg Gynecol Obstet. 1970 Mar;130(3):431-8 PMID: 5413426

Article Info

Journal

Annals of surgery

Abbr.

Ann Surg

ISSN

0003-4932

DOI

10.1097/00000658-197712000-00015

Published

1977-12-00

Pages

746-8

Language

English

Region

United States

NLM ID

0372354

PMCID

PMC1396528

Subset

External Links

PubMed source DOI: 10.1097/00000658-197712000-00015 PMC Full Text View journal details

Analysis Services

Neutrophil chemotaxis in patients with burns.

Contact

WeChat Official Account