Intercellular communication and tissue growth. I. Cancerous growth.

The Journal of cell biology ·Vol. 33 ·No. 2 ·1967-05-00 ·Pages 225-34

Loewenstein WR, Kanno Y

Abstract

Intercellular communication was examined with intracellular electrical techniques in primary and transplanted rat liver cancers. Normal liver cells communicate rather freely with each other through permeable junctional membranes. Cancer liver cells show no communication at all; their surface membrane is a strong barrier to diffusion all around the cell. Cancer cells induce alterations in membrane permeability in normal liver cells; communication among the latter is markedly reduced when cancer cells grow near them.

MeSH Terms

Animals Biological Transport Cell Membrane/physiology Cell Membrane Permeability Culture Techniques Electrophysiology/instrumentation Liver/physiology Liver Neoplasms/physiopathology Mathematics Membrane Potentials Neoplasms, Experimental Rats

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Loewenstein W R

Kanno Y

References (16)

16 references, click to expand

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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.33.2.225

Published

1967-05-00

Pages

225-34

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2108359

Subset

External Links

PubMed source DOI: 10.1083/jcb.33.2.225 PMC Full Text View journal details

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Intercellular communication and tissue growth. I. Cancerous growth.

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