Home LiteratureArticle Details
PMID: 6049392 Published · ppublish English Journal Article

Gluconeogenesis from amino acids in neonatal rat liver.

The Biochemical journal ·Vol. 103 ·No. 3 ·1967-06-00 ·Pages 744-8

Yeung D, Oliver IT

Abstract

1. The utilization of amino acids for gluconeogenesis by rat liver develops in postnatal life, reaching maximum activity at the fifth day. 2. The activity of aspartate transaminase shows a similar trend in postnatal development and the increased activity appears to be due to the soluble enzyme. 3. The activity of alanine transaminase is low in foetal and postnatal rat liver and increases in activity at about the twentieth day. 4. Aspartate, glutamate and alanine make a major contribution to gluconeogenesis in the postnatal rat liver.

MeSH Terms
Alanine/metabolism Alanine Transaminase/metabolism Amino Acids/metabolism Animals Animals, Newborn/metabolism Arginine/metabolism Aspartate Aminotransferases/metabolism Aspartic Acid/metabolism Gluconeogenesis Glutamates/metabolism Glycine/metabolism Histidine/metabolism In Vitro Techniques Leucine/metabolism Liver/enzymology,growth & development,metabolism Liver Glycogen/biosynthesis Phenylalanine/metabolism Proline/metabolism Rats Serine/metabolism Spectrophotometry Threonine/metabolism Tyrosine/metabolism Valine/metabolism
Chemicals
Amino Acids Glutamates Liver Glycogen Threonine Aspartic Acid Tyrosine Serine Phenylalanine Histidine Arginine Proline Aspartate Aminotransferases Alanine Transaminase Leucine Valine Alanine Glycine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yeung D
Oliver I T
References (21)
21 references, click to expand
  1. Distribution of transaminases in rat organs.
    J Biol Chem. 1952 Feb;194(2):497-502 PMID: 14927640
  2. CARBOHYDRATE METABOLISM IN LIVER FROM FOETAL AND NEONATAL SHEEP.
    Biochem J. 1965 Apr;95:191-200 PMID: 14333556
  3. A rapid method for the estimation of the glutamic-aspartic transaminase in tissues and its application to radiation sickness.
    Arch Biochem. 1950 Aug;28(1):36-42 PMID: 14771923
  4. Plasma albumin synthesis during neonatal development of the rat.
    Biochem J. 1967 Mar;102(3):760-2 PMID: 16742491
  5. Paths of carbon in gluconeogenesis and lipogenesis: the role of mitochondria in supplying precursors of phosphoenolpyruvate.
    Proc Natl Acad Sci U S A. 1965 Jun;53(6):1410-5 PMID: 5217643
  6. Glucose-6-phosphate utilization in hepatoma, regenerating and newborn rat liver, and in the liver of fed and fasted normal rats.
    Cancer Res. 1957 Nov;17(10):995-1005 PMID: 13489700
  7. Hepatic metabolism of phenylalanine during development.
    J Clin Invest. 1959 Dec;38:2189-96 PMID: 14408533
  8. Enzymatic patterns during development; an approach to a biochemical definition of immaturity.
    Pediatrics. 1959 Mar;23(3):606-17 PMID: 13633377
  9. Autolytic changes in foetal liver.
    J Pathol Bacteriol. 1960 Apr;79:289-94 PMID: 13814571
  10. THE METABOLISM OF HISTIDINE. LIVER-ENZYME CHANGES DURING DEVELOPMENT.
    Biochim Biophys Acta. 1964 Aug 19;90:282-6 PMID: 14220712
  11. Changes in patterns of enzymes of carbohydrate metabolism in the developing rat liver.
    J Biol Chem. 1963 Jul;238:2267-73 PMID: 14016891
  12. Tryptophan peroxidase-oxidase, histidase, and transaminase activity in the liver of the developing rat.
    J Biol Chem. 1959 Feb;234(2):304-6 PMID: 13630899
  13. Glycogen metabolism in embryonic chick and neonatal rat liver.
    Biochim Biophys Acta. 1963 Jun 4;71:578-88 PMID: 13966157
  14. Ketohexokinase, isoenzymes of glucokinase and glycogen synthesis from hexoses in neonatal rat liver.
    Biochem J. 1964 Feb;90(2):261-8 PMID: 5834236
  15. Appearance of fructose-1,6-diphosphatase in post-natal rat liver.
    Nature. 1962 Aug 4;195:498-9 PMID: 13864432
  16. Amino acid metabolism of growing tissues. II. Alanine-glutamic acid transaminase activity of embryonic rat liver.
    Exp Cell Res. 1961 Jan;22:120-36 PMID: 13791280
  17. Certain aspects of tyrosine metabolism in the young. II. The tyrosine oxidizing system of fetal rat liver.
    J Clin Invest. 1956 Oct;35(10):1089-93 PMID: 13367205
  18. A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum.
    J Clin Invest. 1955 Jan;34(1):131-3 PMID: 13221664
  19. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  20. TRANSAMINASE ACTIVITIES IN SOME RAPIDLY GROWING TISSUE.
    J Biochem. 1964 Feb;55:199-201 PMID: 14135464
  21. Certain aspects of tyrosine metabolism in the young. I. The development of the tyrosine oxidizing system in human liver.
    J Clin Invest. 1956 Feb;35(2):236-44 PMID: 13286342
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1030744
Published
1967-06-00
Pages
744-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1270478
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1030744 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2