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PMID: 6049858 Published · ppublish English Journal Article

The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland.

The Biochemical journal ·Vol. 104 ·No. 3 ·1967-09-00 ·Pages 1075-81

Mangan FR, Neal GE, Williams DC

Abstract

1. Implantation of diethylstilboestrol pellets into adult male rats brings about similar biochemical changes in the nucleic acid and protein metabolism to castration. 2. The avidity of the prostate for labelled diethylstilboestrol was greater than that of the other organs examined. 3. Uptake of labelled diethylstilboestrol and testosterone into the nuclei of the rat prostate is greater in castrated rats than in controls. 4. Diethylstilboestrol appeared to be associated with the protein and not with the DNA fraction of the nucleus.

MeSH Terms
Animals Carbon Isotopes Castration Centrifugation, Density Gradient Diethylstilbestrol/administration & dosage,pharmacology Male Nucleic Acids/metabolism Phenylalanine/metabolism Prostate/drug effects RNA Nucleotidyltransferases/metabolism Rats Testosterone/metabolism Tritium
Chemicals
Carbon Isotopes Nucleic Acids Tritium Testosterone Phenylalanine Diethylstilbestrol RNA Nucleotidyltransferases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mangan F R
Neal G E
Williams D C
References (24)
24 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1041075
Published
1967-09-00
Pages
1075-81
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1271254
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1041075 PMC Full Text View journal details
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