Pathological study on amyloidosis--scanning electron microscopic observation of amyloid-laden mouse liver.

Amyloidosis of liver in mice induced by casein injection was studied by scanning electron microscopy (SEM). In the fractured-surfaces of the central portion of amyloid nodules, they appeared as chestnut-bur-like structures and were composed of numerous thread-like structures of fasciculated amyloid fibrils and of stick-like structures of amyloid bundles in three dimensional figure. In the cytoplasm of the Kupffer cell, amyloid bundles were revealed as band-like bulges. These bulges were projected from the Kupffer cell into the Disse's space and continued with thread-like structures outside the cytoplasm of Kupffer cells.