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PMID: 6083453 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing.

Nature ·Vol. 312 ·No. 5996 ·1984-00-00 ·Pages 729-34

Nawa H, Kotani H, Nakanishi S

Abstract

A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cattle Cloning, Molecular Gene Expression Regulation Genes Nerve Tissue Proteins/genetics Nervous System Physiological Phenomena Peptides/genetics Protein Precursors/genetics RNA Splicing RNA, Messenger/genetics Substance P/genetics Tachykinins Tissue Distribution

Chemicals

Nerve Tissue Proteins Peptides Protein Precursors RNA, Messenger Tachykinins preprotachykinin Substance P

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Nawa H

Kotani H

Nakanishi S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/312729a0

Published

1984-00-00

Pages

729-34

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

M14786, X00075, X00076, X01395, X01396, X01397, X01398, X01399, X01400, X01401, X02351

External Links

PubMed source DOI: 10.1038/312729a0 View journal details

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Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing.

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