Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors.

Ultrastructural pathology ·Vol. 7 ·No. 2-3 ·1984-00-00 ·Pages 83-107

Miettinen M, Lehto VP, Virtanen I

Abstract

Immunohistochemistry of intermediate filaments (IF) is a new and important way to evaluate the epithelial, mesenchymal, muscular, glial, or neural differentiation in tumors. This is based on the stable cell-type-specific expression of IF proteins in normal and neoplastic tissues. Immunohistochemical studies with antibodies to intermediate filaments have also given new perspectives in the histogenesis and biologic nature of many tumors. This article reviews both the recent findings and the authors' experience in the use of intermediate filament antibodies in tumor diagnosis and classification.

MeSH Terms

Adenocarcinoma/diagnosis Antibodies, Neoplasm/analysis Carcinoma, Squamous Cell/diagnosis Desmin/immunology Diagnosis, Differential Glial Fibrillary Acidic Protein/immunology Histocytochemistry Humans Immunochemistry Keratins/immunology Melanoma/diagnosis Mesothelioma/diagnosis Microfilament Proteins/immunology Microscopy, Electron Neoplasm Proteins/immunology Neoplasms/classification,diagnosis Nervous System Neoplasms/diagnosis Sarcoma/diagnosis Soft Tissue Neoplasms/diagnosis Thyroid Neoplasms/diagnosis Urinary Bladder Neoplasms/diagnosis Vimentin/immunology

Chemicals

Antibodies, Neoplasm Desmin Glial Fibrillary Acidic Protein Microfilament Proteins Neoplasm Proteins Vimentin Keratins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Miettinen M

Lehto V P

Virtanen I

Article Info

Journal

Ultrastructural pathology

Abbr.

Ultrastruct Pathol

ISSN

0191-3123

DOI

10.3109/01913128409141467

Published

1984-00-00

Pages

83-107

Language

English

Region

England

NLM ID

8002867

Subset

External Links

PubMed source DOI: 10.3109/01913128409141467 View journal details

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Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors.

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