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PMID: 6086815 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA.

The Journal of general virology ·Vol. 65 ( Pt 7) ·1984-07-00 ·Pages 1225-8

Fenwick ML, McMenamin MM

Abstract

Vero cells infected with herpes simplex virus in the presence of actinomycin or cycloheximide, or with u.v.-inactivated virus, suffered a rapid loss of functional mRNA as determined by translation in vitro. It is suggested that a virion-associated factor causes a structural change in the mRNA of the host cell.

MeSH Terms
Animals Cells, Cultured Gene Expression Regulation Herpes Simplex/genetics Polyribosomes/metabolism Protein Biosynthesis RNA, Messenger/genetics,metabolism Simplexvirus/genetics
Chemicals
RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fenwick M L
McMenamin M M
Article Info
Journal
The Journal of general virology
Abbr.
J Gen Virol
ISSN
0022-1317
DOI
10.1099/0022-1317-65-7-1225
Published
1984-07-00
Pages
1225-8
Language
English
Region
England
NLM ID
0077340
Subset
IM
External Links
PubMed source DOI: 10.1099/0022-1317-65-7-1225 View journal details
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