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PMID: 6089346 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DNA markers for nervous system diseases.

Science (New York, N.Y.) ·Vol. 225 ·No. 4668 ·1984-09-21 ·Pages 1320-6

Gusella JF, Tanzi RE, Anderson MA, Hobbs W, Gibbons K, Raschtchian R, Gilliam TC, Wallace MR, Wexler NS, Conneally PM

Abstract

Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.

MeSH Terms

Alleles Base Sequence Chromosome Mapping Cloning, Molecular DNA/genetics DNA Restriction Enzymes DNA, Recombinant Female Genes Genetic Linkage Genetic Markers Genetic Vectors Humans Huntington Disease/genetics Male Mutation Pedigree Phenotype Polymorphism, Genetic

Chemicals

DNA, Recombinant Genetic Markers DNA DNA Restriction Enzymes

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Gusella J F

Tanzi R E

Anderson M A

Hobbs W

Gibbons K

Raschtchian R

Gilliam T C

Wallace M R

Wexler N S

Conneally P M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6089346

Published

1984-09-21

Pages

1320-6

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NINDS NIH HHS · NS16367 · United States

NINDS NIH HHS · NS20012 · United States

External Links

PubMed source DOI: 10.1126/science.6089346 View journal details

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