The Ca2+/C1- dependent L-[3H]glutamate binding: a new receptor or a particular transport process?

Ca2+/C1- increases the L-[3H]glutamate binding to rat brain synaptic membranes. It was suggested that Ca2+/C1- expresses a new class of glutamate receptors. We report several lines of evidence suggesting that Ca2+/C1- in fact favours a glutamate transport into membrane vesicles. This finding may serve to reconcile most of the discrepancies found in the literature on the glutamate binding and its pharmacology.