Rhodopsin kinase activity in the mammalian pineal gland and other tissues.

Science (New York, N.Y.) ·Vol. 226 ·No. 4671 ·1984-10-12 ·Pages 182-4

Somers RL, Klein DC

Abstract

Rhodopsin kinase, an enzyme involved in photochemical transduction in the retina, has been found in the mammalian pineal gland in amounts equal to those in the retina; other tissues had 7 percent of this amount, or less. This finding suggests that, in mammals, rhodopsin kinase functions in the pineal gland and other tissues to phosphorylate rhodopsin-like integral membrane receptors and is thereby involved in signal transduction.

MeSH Terms

Animals Brain/enzymology Eye Proteins G-Protein-Coupled Receptor Kinase 1 Light Lung/enzymology Phosphorylation Pineal Gland/enzymology Pituitary Gland/enzymology Protein Kinase Inhibitors Protein Kinases/metabolism Rats Receptors, Adrenergic, beta/metabolism Retina/enzymology Tissue Distribution Zinc/pharmacology

Chemicals

Eye Proteins Protein Kinase Inhibitors Receptors, Adrenergic, beta Protein Kinases G-Protein-Coupled Receptor Kinase 1 Grk1 protein, rat Zinc

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Somers R L

Klein D C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6091271

Published

1984-10-12

Pages

182-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.6091271 View journal details

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Rhodopsin kinase activity in the mammalian pineal gland and other tissues.

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