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PMID: 6094241
Published · ppublish
English
Journal Article
Xanthine oxidase induced depolymerization of hyaluronic acid in the presence of ferritin.
Abstract
Oxygen free radicals generated by xanthine oxidase are able to depolymerize hyaluronic acid in the presence of ferritin-bound iron. This suggests that ferritin can catalyse the Haber-Weiss reaction, leading to the formation of highly damaging hydroxyl radicals.
MeSH Terms
Animals
Cattle
Chemical Phenomena
Chemistry
Deferoxamine/pharmacology
Edetic Acid/pharmacology
Ferritins/pharmacology
Hyaluronic Acid/metabolism
Hydroxides/metabolism
Hydroxyl Radical
Superoxides/metabolism
Viscosity
Xanthine Oxidase/metabolism
Chemicals
Hydroxides
Superoxides
Hydroxyl Radical
Hyaluronic Acid
Ferritins
Edetic Acid
Xanthine Oxidase
Deferoxamine
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
Published
1984-11-05
Pages
27-30
Language
English
Region
England
NLM ID
0155157
Subset
IM
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