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PMID: 6095113 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription.

Nature ·Vol. 312 ·No. 5995 ·1984-00-00 ·Pages 608-12

Borrelli E, Hen R, Chambon P

Abstract

The adenovirus-2 early region 1A (E1A) products repress activation of transcription induced by the simian virus 40, polyoma virus and adenovirus-2 E1A enhancers. The repression probably involves an interaction between the enhancer elements and a trans-acting factor(s), possibly the E1A products themselves.

MeSH Terms
Adenoviruses, Human/genetics Base Sequence Cell Line Cell Transformation, Viral DNA Restriction Enzymes Enhancer Elements, Genetic Genes, Regulator Genes, Viral HeLa Cells/metabolism Humans Plasmids Promoter Regions, Genetic Simian virus 40/genetics Transcription, Genetic Transfection
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Borrelli E
Hen R
Chambon P
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1984-00-00
Pages
608-12
Language
English
Region
England
NLM ID
0410462
Subset
IM
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