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PMID: 6095275 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Slow virus visna: reproduction in vitro of virus from extrachromosomal DNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 22 ·1984-11-00 ·Pages 7212-5

Harris JD, Blum H, Scott J, Traynor B, Ventura P, Haase A

Abstract

Under permissive conditions of growth in tissue culture, the retrovirus visna multiples over the course of a few days to high titer and kills the host cell. We show that in this lytic life cycle, viral DNA is tightly associated with, but not covalently linked to, chromosomal DNA. This finding provides explanations for a number of the unusual properties of the lentivirus subfamily of retroviruses, and suggests potential mechanisms for the block in virus gene expression in vivo responsible for the slow infection in nature.

MeSH Terms
DNA Replication DNA Restriction Enzymes DNA, Viral/genetics Extrachromosomal Inheritance Molecular Weight Nucleic Acid Hybridization Virus Replication Visna-maedi virus/genetics,growth & development
Chemicals
DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Harris J D
Blum H
Scott J
Traynor B
Ventura P
Haase A
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.22.7212
Published
1984-11-00
Pages
7212-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392108
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.81.22.7212 PMC Full Text View journal details
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