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PMID: 6095452 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA.

Science (New York, N.Y.) ·Vol. 226 ·No. 4680 ·1984-12-14 ·Pages 1322-5

Matsuo T, Heller M, Petti L, O'Shiro E, Kieff E

Abstract

The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.

MeSH Terms

Base Sequence Burkitt Lymphoma/microbiology DNA, Viral/analysis Herpesvirus 4, Human/genetics Humans Lymphocytes/ultrastructure Nucleic Acid Hybridization Plasmids Recombination, Genetic

Chemicals

DNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Matsuo T

Heller M

Petti L

O'Shiro E

Kieff E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6095452

Published

1984-12-14

Pages

1322-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI07099 · United States

NCI NIH HHS · CA 17281 · United States

NCI NIH HHS · CA 19264 · United States

Databases

GENBANK

K02579, K02580, K02710, K02711

External Links

PubMed source DOI: 10.1126/science.6095452 View journal details

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Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA.

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