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PMID: 6098468 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.

The EMBO journal ·Vol. 3 ·No. 13 ·1984-12-20 ·Pages 3215-22

Selten G, Cuypers HT, Zijlstra M, Melief C, Berns A

Abstract

In approximately 45% of the murine leukemia virus (MuLV) induced early developing T cell lymphomas in mice, integration of proviruses occurs near c-myc. From the 33 lymphomas with proviral integrations in the c-myc domain, 29 insertions were localized upstream of the first exon in a region spanning less than 2 kbp, and four integrations occurred within the first exon. In 90% of the lymphomas the transcriptional orientation of the proviruses was opposite to the transcriptional direction of c-myc. In 20% of the early T cell lymphomas, proviral integrations were detected both near c-myc and the pim-1 gene. They comprise both lymphomas in which integration near c-myc and pim-1 occurred in separate tumor cell populations, as well as tumors in which proviral integration near c-myc and pim-1 occurred in the same cell clone. Proviral integration in the c-myc domain is associated with increased myc mRNA levels (up to 30-fold). The size and nature of the c-myc mRNA precursors and processed transcripts depend on the position and orientation of the integrated proviruses.

MeSH Terms
Animals Leukemia Virus, Murine/genetics Lymphoma/etiology Lysogeny Mice Mice, Inbred Strains Oncogenes RNA, Messenger/genetics RNA, Neoplasm/genetics T-Lymphocytes Transcription, Genetic Virus Activation
Chemicals
RNA, Messenger RNA, Neoplasm
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Selten G
Cuypers H T
Zijlstra M
Melief C
Berns A
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53 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-12-20
Pages
3215-22
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557840
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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