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PMID: 6110221 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Sequential conversion of the glutathionyl side chain of slow reacting substance (SRS) to cysteinyl-glycine and cysteine in rat basophilic leukemia cells stimulated with A-23187.

Prostaglandins ·Vol. 20 ·No. 5 ·1980-11-00 ·Pages 863-86

Parker CW, Falkenhein SF, Huber MM

Abstract

In rat basophilic leukemia (RBL-1) cells stimulated with A-23187, the major slow reacting substance (SRS) species contain glutathione, cysteinyl-glycine, or cysteine in their side chains, corresponding or closely related to leukotrienes LTC4, LTD4, and LTE4, respectively. Evidence is presented that most of the SRS produced during the first few minutes of stimulation by the ionophore has a glutathionyl side chain which is sequentially converted to cysteinyl-glycine and cysteine.

MeSH Terms
Animals Anti-Bacterial Agents/pharmacology Arachidonic Acids/metabolism Autacoids/metabolism Basophils/drug effects,metabolism Calcimycin/pharmacology Cells, Cultured Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Cysteine/metabolism Dipeptides/metabolism Glutathione/metabolism Guinea Pigs Leukemia, Experimental/metabolism Rats SRS-A gamma-Glutamyltransferase/metabolism
Chemicals
Anti-Bacterial Agents Arachidonic Acids Autacoids Dipeptides SRS-A Calcimycin cysteinylglycine gamma-Glutamyltransferase Glutathione Cysteine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Parker C W
Falkenhein S F
Huber M M
Article Info
Journal
Prostaglandins
Abbr.
Prostaglandins
ISSN
0090-6980
DOI
10.1016/0090-6980(80)90139-2
Published
1980-11-00
Pages
863-86
Language
English
Region
United States
NLM ID
0320271
Subset
IM
Grants
NCI NIH HHS · 5 P01 CA 16216 · United States
External Links
PubMed source DOI: 10.1016/0090-6980(80)90139-2
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