Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified K99 or 987P pili: antibody production in response to vaccination.

Infection and immunity ·Vol. 29 ·No. 2 ·1980-08-00 ·Pages 824-6

Isaacson RE, Dean EA, Morgan RL, Moon HW

Abstract

Pilus-specific antibody levels measured by enzyme-linked immunosorbent assays in serum and colostrum of pregnant swine (dams) were shown to increase after parenteral vaccination with pili. Pilus-specific antibody levels in dams were correlated with protection of their suckling offspring against fatal diarrhea caused by enterotoxigenic Escherichia coli possessing the same pilus as the vaccine.

MeSH Terms

Animals Animals, Suckling Antibodies, Bacterial/analysis,immunology Bacterial Vaccines/administration & dosage,immunology Colostrum/immunology Diarrhea/etiology,prevention & control Enterotoxins/metabolism Enzyme-Linked Immunosorbent Assay Escherichia coli/immunology,metabolism Female Fimbriae, Bacterial/immunology Immunization Pregnancy Swine

Chemicals

Antibodies, Bacterial Bacterial Vaccines Enterotoxins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Isaacson R E

Dean E A

Morgan R L

Moon H W

References (11)

11 references, click to expand

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Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.
J Immunol. 1972 Jul;109(1):129-35 PMID: 4113792
Role of the K88 antigen in the pathogenesis of neonatal diarrhea caused by Escherichia coli in piglets.
Infect Immun. 1972 Dec;6(6):918-27 PMID: 4629393
Contribution of the K88 antigen of Escherichia coli to enteropathogenicity; protection against disease by neutralizing the adhesive properties of K88 antigen.
Am J Clin Nutr. 1974 Dec;27(12):1441-9 PMID: 4611195
Protection against neonatal enteric colibacillosis in pigs suckling orally vaccinated sows.
Am J Vet Res. 1975 Jun;36(6):757-64 PMID: 1096687
K99 surface antigen of Escherichia coli: purification and partial characterization.
Infect Immun. 1977 Jan;15(1):272-9 PMID: 401772
Occurrence of K99 antigen on Escherichia coli isolated from pigs and colonization of pig ileum by K99+ enterotoxigenic E. coli from calves and pigs.
Infect Immun. 1977 Feb;15(2):614-20 PMID: 321356
Colonization of porcine small intestine by Escherichia coli: colonization and adhesion factors of pig enteropathogens that lack K88.
J Infect Dis. 1977 Apr;135(4):531-9 PMID: 323375
Immunization of suckling pigs against enteric enterotoxigenic Escherichia coli infection by vaccinating dams with purified pili.
Infect Immun. 1978 Jul;21(1):269-74 PMID: 361566
Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified 987 or K99 pili: protection correlates with pilus homology of vaccine and challenge.
Infect Immun. 1978 Dec;22(3):771-7 PMID: 365769
Immunization of calves against enterotoxigenic colibacillosis by vaccinating dams with purified K99 antigen and whole cell bacterins.
Infect Immun. 1979 Jul;25(1):121-6 PMID: 39031

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.29.2.824-826.1980

Published

1980-08-00

Pages

824-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC551198

Subset

External Links

PubMed source DOI: 10.1128/iai.29.2.824-826.1980 PMC Full Text View journal details

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Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified K99 or 987P pili: antibody production in response to vaccination.

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