Incidence of sulphasalazine-induced male infertility.

Gut ·Vol. 22 ·No. 6 ·1981-06-00 ·Pages 452-5

Birnie GG, McLeod TI, Watkinson G

Abstract

Sperm analysis of 21 patients taking sulphasalazine for inflammatory bowel disease revealed that 86% had abnormal semen analysis and 72% had oligospermia.

MeSH Terms

Adolescent Adult Colitis, Ulcerative/drug therapy Crohn Disease/drug therapy Humans Infertility, Male/chemically induced,epidemiology Male Middle Aged Spermatozoa/drug effects Sulfasalazine/adverse effects,therapeutic use

Chemicals

Sulfasalazine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Birnie G G

McLeod T I

Watkinson G

References (6)

6 references, click to expand

Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype.
N Engl J Med. 1973 Sep 6;289(10):491-5 PMID: 4146729
A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin).
Gut. 1973 Dec;14(12):923-6 PMID: 4150435
Sulphasalazine and salicylazosulphadimidine in ulcerative colitis.
Lancet. 1962 May 26;1(7239):1094-6 PMID: 13865153
Male infertility due to sulphasalazine.
Lancet. 1979 Aug 11;2(8137):276-8 PMID: 88609
National Cooperative Crohn's Disease Study: results of drug treatment.
Gastroenterology. 1979 Oct;77(4 Pt 2):847-69 PMID: 38176
Further studies of sulphasalazine metabolism in the treatment of ulcerative colitis.
Br Med J. 1977 Oct 22;2(6094):1057-9 PMID: 21720

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.22.6.452

Published

1981-06-00

Pages

452-5

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1419273

Subset

External Links

PubMed source DOI: 10.1136/gut.22.6.452 PMC Full Text View journal details

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Incidence of sulphasalazine-induced male infertility.

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