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PMID: 6115382 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Antihistaminics, local anesthetics, and other amines as antiviral agents.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 6 ·1981-06-00 ·Pages 3605-9

Miller DK, Lenard J

Abstract

A number of lipophilic amines of diverse chemical structure, including antihistaminics, local anesthetics, and chloroquine, were found to exhibit similar kinetics in inhibiting the infection of BHK cells by vesicular stomatitis virus. The inhibition occurred prior to both primary and secondary RNA transcription but following transfer from the cell surface to an intracellular site, presumed to be the lysosomes. A similar inhibition, by these agents, of infection by Sendai, influenza strain WSN, and Semliki Forest viruses suggested a lysosomal involvement in infection by these viruses as well.

MeSH Terms
Amines/pharmacology Anesthetics, Local/pharmacology Antiviral Agents Histamine H1 Antagonists/pharmacology Orthomyxoviridae/drug effects Parainfluenza Virus 1, Human/drug effects RNA, Viral/biosynthesis Semliki forest virus/drug effects Vesicular stomatitis Indiana virus/drug effects Virus Replication/drug effects
Chemicals
Amines Anesthetics, Local Antiviral Agents Histamine H1 Antagonists RNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Miller D K
Lenard J
References (22)
22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.6.3605
Published
1981-06-00
Pages
3605-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319619
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.6.3605 PMC Full Text View journal details
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