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PMID: 6120875 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Absence of islet alpha cell function in pancreatectomized patients.

Diabetologia ·Vol. 22 ·No. 1 ·1982-01-00 ·Pages 25-32

Tiengo A, Bessioud M, Valverde I, Tabbi-Anneni A, Delprato S, Alexandre J, Assan R

Abstract

Plasma immunoreactive glucagon, C-peptide and substrates (glucose, lactate, and alanine) were measured in 21 pancreatectomized patients and 28 patients with chronic calcifying pancreatitis during arginine infusion. Results were compared with those obtained in control and in insulin-dependent diabetic subjects, and in pancreatectomized subjects receiving a combined infusion of glucagon and arginine or somatostatin and arginine. Plasma immunoreactive glucagon in the pancreatectomized patients was 230 +/- 26 pg/ml (control subjects 100 +/- 13 pg/ml, p less than 0.001), but was unchanged following arginine or somatostatin. Following ethanol extraction of plasma it became undetectable. Similar results were obtained in patients with chronic pancreatitis. In contrast to the insulin-dependent diabetic subjects, no changes in blood glucose, lactate, and alanine concentrations were found during arginine infusion in the pancreatectomized or pancreatitis patients. Addition of glucagon restored the metabolic response to arginine in the pancreatectomized patients. Our results confirm previous smaller studies that in pancreatectomized patients, A cell function is absent or insignificant.

MeSH Terms
Adult Arginine C-Peptide/blood Diabetes Mellitus/blood,physiopathology Female Glucagon/immunology Humans Islets of Langerhans/physiopathology Male Pancreatectomy Pancreatic Function Tests Pancreatitis/blood,physiopathology Somatostatin
Chemicals
C-Peptide Somatostatin Glucagon Arginine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Tiengo A
Bessioud M
Valverde I
Tabbi-Anneni A
Delprato S
Alexandre J
Assan R
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36 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00253865
Published
1982-01-00
Pages
25-32
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00253865 View journal details
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