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PMID: 6121318 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Coordinate regulation of ribosomal protein mRNA level in regenerating rat liver. Study with the corresponding mouse cloned cDNAs.

Nucleic acids research ·Vol. 10 ·No. 3 ·1982-02-11 ·Pages 789-801

Faliks D, Meyuhas O

Abstract

Cloned mouse ribosomal protein (rp) cDNAs exhibit extensive homology with the corresponding rat sequences. The size of the rp-mRNAs and complexity of the rp-genes are very similar in the two species. Using the mouse rp-recombinant DNAs we find that the relative abundance of rat L7, L13, L18, L30, L32/33 and S16 mRNAs increases after partial hepatectomy. Their maximal level is about twice that of normal rat liver, and is achieved 12-18 h after the operation, while the relative abundance of albumin mRNA decreases to half the normal values 12 h after partial hepatectomy. This concomitant increase in the relative content of these rp-mRNAs indicates coordinate regulation of their level in the rat. The dissimilar behavior of L10 and L19 rp-mRNA suggests additional control mechanisms of rp-mRNA levels in the regenerating rat liver.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA/metabolism Drug Stability Liver/metabolism Liver Regeneration Male Mice Mice, Inbred Strains Nucleic Acid Hybridization Poly A/genetics RNA, Messenger/genetics Rats Rats, Inbred Strains Ribosomal Proteins/genetics
Chemicals
RNA, Messenger Ribosomal Proteins Poly A DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Faliks D
Meyuhas O
References (32)
32 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.3.789
Published
1982-02-11
Pages
789-801
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326203
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/10.3.789 PMC Full Text View journal details
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