Unsuitability of urethane anesthetized rats for testing potential beta-adrenoreceptor blockers.

Experientia ·Vol. 38 ·No. 4 ·1982-04-15 ·Pages 517-9

Maggi CA, Meli A

Abstract

暂无摘要

MeSH Terms

Adrenergic alpha-Antagonists/pharmacology Anesthesia, General Animals Barbital/pharmacology Blood Pressure/drug effects Heart Rate/drug effects Isoproterenol/pharmacology Male Practolol/pharmacology Propranolol/pharmacology Rats Rats, Inbred Strains Urethane/pharmacology

Chemicals

Adrenergic alpha-Antagonists Urethane Barbital Propranolol Isoproterenol Practolol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Maggi C A

Meli A

References (12)

12 references, click to expand

The assessment of -adrenoceptor blocking potency and cardioselectivity in vitro and in vivo.
J Pharm Pharmacol. 1972 Nov;24(11):880-5 PMID: 4405651
Urethane and contraction of vascular smooth muscle.
Br J Pharmacol. 1979 Oct;67(2):255-63 PMID: 497529
Beta-adrenoceptor-blocking agents: pharmacokinetic differences and their clinical implications illustrated on pindolol.
Cardiology. 1979;64 Suppl 1:1-13 PMID: 42483
Microcirculatory actions of general anesthetics.
Fed Proc. 1980 Apr;39(5):1580-3 PMID: 7364055
Proceedings: Effects of adrenaline on membrane currents underlying pacemaker activity in frog atrial muscle.
J Physiol. 1974 Apr;238(1):51P-53P PMID: 4546150
Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics.
Br J Pharmacol. 1973 Dec;49(4):565-72 PMID: 4788029
Anesthesia-induced alteration of small vessel response to norepinephrine.
Eur J Pharmacol. 1977 Aug 15;44(4):331-7 PMID: 891609
The hypocalcemic effect of urethane in rats.
J Pharmacol Exp Ther. 1972 Sep;182(3):522-7 PMID: 5055410
A NEW ADRENERGIC BETARECEPTOR ANTAGONIST.
Lancet. 1964 May 16;1(7342):1080-1 PMID: 14132613
Responses to pressor substances in conscious and anaesthetized cats.
Br J Pharmacol. 1971 Nov;43(3):668-70 PMID: 5157727
Augmentation of drug-induced blood pressure increases in rats by amorbarbital.
Br J Pharmacol. 1972 Nov;46(3):511-3 PMID: 4348181
Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade.
Clin Pharmacol Ther. 1977 May;21(5):556-66 PMID: 15753

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01952672

Published

1982-04-15

Pages

517-9

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01952672

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Unsuitability of urethane anesthetized rats for testing potential beta-adrenoreceptor blockers.

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