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PMID: 6124417 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Induction of cytosolic tyrosine aminotransferase by dexamethasone in organ culture of fetal human liver.

Early human development ·Vol. 6 ·No. 2 ·1982-04-00 ·Pages 165-9

Andersson SM

Abstract

Total tyrosine aminotransferase activity in organ culture of fetal human liver is increased by 347% after 15 h incubation with 2 micro M of dexamethasone. Isoelectric focusing reveals that the increased activity is due to induction of cytosolic tyrosine aminotransferase (EC 2.6.1.5) while the activity of the nonspecific mitochondrial aspartate aminotransferase (EC 2.6.1.1) remains unchanged.

MeSH Terms
Aspartate Aminotransferases/biosynthesis Culture Techniques Cytosol/enzymology Dexamethasone/pharmacology Enzyme Induction Fetus/enzymology Humans Liver/embryology,enzymology Mitochondria, Liver/enzymology Tyrosine Transaminase/biosynthesis
Chemicals
Dexamethasone Aspartate Aminotransferases Tyrosine Transaminase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Andersson S M
Article Info
Journal
Early human development
Abbr.
Early Hum Dev
ISSN
0378-3782
DOI
10.1016/0378-3782(82)90104-9
Published
1982-04-00
Pages
165-9
Language
English
Region
Ireland
NLM ID
7708381
Subset
IM
External Links
PubMed source DOI: 10.1016/0378-3782(82)90104-9 View journal details
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