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PMID: 6124427 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Thy-1 determinants are present on many murine hematopoietic cells other than T cells.

European journal of immunology ·Vol. 12 ·No. 5 ·1982-05-00 ·Pages 359-64

Basch RS, Berman JW

Abstract

The development of a highly amplified immunofluorescence assay and the availability of monoclonal anti-Thy-1 antibodies have provided the methodology to reexamine the presence of Thy-1 antigen on murine lymphohematopoietic cells. The representation of this antigen is not, as previously believed, restricted to the T cell compartment of these cells. It is present on a significant number of mouse bone marrow cells (25-30%), including, as in the rat, multipotential stem cells, prothymocytes and some B cell precursors. Eosinophils and some immature myeloid cells are also antigen-positive.

MeSH Terms

Animals Antigens, Surface Bone Marrow/immunology Bone Marrow Cells Cell Differentiation Cell Separation Colony-Forming Units Assay Flow Cytometry Granulocytes/cytology,immunology Hematopoietic Stem Cells/immunology Immune Sera/pharmacology Mice Mice, Inbred A Mice, Inbred AKR Mice, Inbred C57BL Mice, Inbred DBA Monocytes/cytology,immunology Rabbits Rats T-Lymphocytes/classification,cytology,immunology Thy-1 Antigens

Chemicals

Antigens, Surface Immune Sera Thy-1 Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Basch R S

Berman J W

Article Info

Journal

European journal of immunology

Abbr.

Eur J Immunol

ISSN

0014-2980

DOI

10.1002/eji.1830120502

Published

1982-05-00

Pages

359-64

Language

English

Region

Germany

NLM ID

1273201

Subset

Grants

NCI NIH HHS · CA 09161 · United States

NCI NIH HHS · CA 24472 · United States

External Links

PubMed source DOI: 10.1002/eji.1830120502 View journal details

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Thy-1 determinants are present on many murine hematopoietic cells other than T cells.

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