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PMID: 6136748 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue.

Lancet (London, England) ·Vol. 2 ·No. 8350 ·1983-09-10 ·Pages 599-602

Letvin NL, Aldrich WR, King NW, Blake BJ, Daniel MD, Hunt RD

Abstract

Acquired immuno-deficiency syndrome (AIDS) of macaques, an animal model for human AIDS, was transmitted to previously healthy macaque monkeys by means of inoculation of either tissue or a cell-free filtrate of a macaque lymphoma. The recipients showed evidence of profound lymphocyte dysfunction or died with infections from such opportunistic agents as Candida albicans, Cryptosporidium, and cytomegalovirus.

MeSH Terms

Acquired Immunodeficiency Syndrome/complications,transmission,veterinary Animals Candidiasis/etiology Cytomegalovirus Infections/etiology Disease Models, Animal Female Intestinal Neoplasms/transmission Lymphoma/transmission,veterinary Macaca/microbiology Macaca fascicularis/microbiology Macaca mulatta/microbiology Male Monkey Diseases/transmission Neoplasms, Experimental/transmission T-Lymphocytes/immunology

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Letvin N L

Aldrich W R

King N W

Blake B J

Daniel M D

Hunt R D

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(83)90682-7

Published

1983-09-10

Pages

599-602

Language

English

Region

England

NLM ID

2985213R

Subset

Grants

NCRR NIH HHS · RR00168 · United States

External Links

PubMed source DOI: 10.1016/s0140-6736(83)90682-7 View journal details

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Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue.

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