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PMID: 6136979 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recording of single gamma-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes.

Proceedings of the Royal Society of London. Series B, Biological sciences ·Vol. 218 ·No. 1213 ·1983-07-22 ·Pages 481-4

Miledi R, Parker I, Sumikawa K

Abstract

High resolution ('giga-seal') patch clamp recording in Xenopus oocytes was used to measure single channel currents from ACh- and GABA-activated receptors. The proteins that make up these receptors had been translated from mRNA derived from, respectively, denervated cat muscle and chick optic lobe.

MeSH Terms

Animals Electrophysiology Female Oocytes/metabolism Protein Biosynthesis RNA, Messenger/metabolism Receptors, Cell Surface/genetics Receptors, Cholinergic/genetics Receptors, GABA-A Xenopus

Chemicals

RNA, Messenger Receptors, Cell Surface Receptors, Cholinergic Receptors, GABA-A

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Miledi R

Parker I

Sumikawa K

Article Info

Journal

Proceedings of the Royal Society of London. Series B, Biological sciences

Abbr.

Proc R Soc Lond B Biol Sci

ISSN

0950-1193

DOI

10.1098/rspb.1983.0053

Published

1983-07-22

Pages

481-4

Language

English

Region

England

NLM ID

7505889

Subset

External Links

PubMed source DOI: 10.1098/rspb.1983.0053 View journal details

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Recording of single gamma-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes.

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