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PMID: 6154527 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition by 2',3'-dideoxythymidine of retroviral infection of mouse and human cells.

Cancer letters ·Vol. 8 ·No. 4 ·1980-02-00 ·Pages 307-15

Furmanski P, Bourguignon GJ, Bolles CS, Corombos JD, Das MR

Abstract

Infection of mouse and human cells with type C murine leukemia/sarcoma viruses was inhibited by the nucleoside analogue 2',3'-dideoxythymidine (ddT). Cell growth and virus synthesis by previously infected cells were not affected by the analogue. Infection of rat cells with murine retroviruses was not inhibited by ddT.

MeSH Terms
Animals Cell Division/drug effects Cell Transformation, Viral/drug effects Cells, Cultured Dideoxynucleosides Humans Kirsten murine sarcoma virus/drug effects Mice Rats Retroviridae/drug effects Reverse Transcriptase Inhibitors Thymidine/analogs & derivatives,pharmacology
Chemicals
Dideoxynucleosides Reverse Transcriptase Inhibitors 2',3'-dideoxythymidine Thymidine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Furmanski P
Bourguignon G J
Bolles C S
Corombos J D
Das M R
Article Info
Journal
Cancer letters
Abbr.
Cancer Lett
ISSN
0304-3835
DOI
10.1016/0304-3835(80)90146-9
Published
1980-02-00
Pages
307-15
Language
English
Region
Ireland
NLM ID
7600053
Subset
IM
External Links
PubMed source DOI: 10.1016/0304-3835(80)90146-9 View journal details
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