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PMID: 6155381 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Demonstration of vasoproliferative activity from mammalian retina.

The Journal of cell biology ·Vol. 84 ·No. 2 ·1980-02-00 ·Pages 298-304

Glaser BM, D'Amore PA, Michels RG, Patz A, Fenselau A

Abstract

Vasoproliferative activity has been demonstrated in extracts of retinas from human, bovine, and feline sources. These retinal extracts are capable of stimulating (a) proliferation and thymidine uptake of bovine vascular endothelial cells in culture and (b) neovascularization on the chick chorioallantoic membrane. Extracts of skeletal muscle, cardiac muscle, and liver lack similar stimulatory activity. The activity is nondialyzable, stable at 56 degrees C, and inactivated at 100 degrees C. Retinal extracts stimulate the proliferation of corneal fibroblasts but have no effect on the proliferation of vascular smooth muscle cells. Indirect evidence suggests the liberation of a vasoproliferative factor from retina in several ocular disorders. The data in this report represent the first direct demonstration of vasoproliferative activity from mammalian retina.

MeSH Terms
Animals Cats Cattle Cell Division/drug effects Chick Embryo Cornea/cytology Endothelium/drug effects,metabolism Extraembryonic Membranes/blood supply,drug effects Female Fibroblasts/drug effects Humans Muscle, Smooth/drug effects Neovascularization, Pathologic Retina/analysis Thymidine/metabolism Tissue Extracts/pharmacology
Chemicals
Tissue Extracts Thymidine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Glaser B M
D'Amore P A
Michels R G
Patz A
Fenselau A
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.84.2.298
Published
1980-02-00
Pages
298-304
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2110559
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.84.2.298 PMC Full Text View journal details
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