Effect of 5-azacytidine on DNA methylation in Ehrlich's ascites tumor cells.

The Australian journal of experimental biology and medical science ·Vol. 58 ·No. 4 ·1980-08-00 ·Pages 391-6

Tanaka M, Hibasami H, Nagai J, Ikeda T

Abstract

5-Azacytidine inhibited in vivo DNA methylation in Ehrlich's ascites tumor cells depending upon the dose at which 5-azacytidine did not inhibit DNA synthesis significantly. This drug did not inhibit DNA methylation in vitro. The DNA methylase activity in ascitic cells decreased with the increasing dose of 5-azacytidine. Hypomethylated DNA was obtained from the 5-azacytidine treated ascitic cells.

MeSH Terms

Animals Azacitidine/pharmacology Carcinoma, Ehrlich Tumor/metabolism DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors DNA, Neoplasm/antagonists & inhibitors Male Mice

Chemicals

DNA, Neoplasm DNA (Cytosine-5-)-Methyltransferases Azacitidine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tanaka M

Hibasami H

Nagai J

Ikeda T

Article Info

Journal

The Australian journal of experimental biology and medical science

Abbr.

Aust J Exp Biol Med Sci

ISSN

0004-945X

DOI

10.1038/icb.1980.39

Published

1980-08-00

Pages

391-6

Language

English

Region

Australia

NLM ID

0416662

Subset

External Links

PubMed source DOI: 10.1038/icb.1980.39

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Effect of 5-azacytidine on DNA methylation in Ehrlich's ascites tumor cells.

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