The 9L rat brain tumor: description and application of an animal model.
Animal models allow determination of tumor response to anticancer agents under various experimental conditions. The chemically induced 9L rat brian tumor has been developed as both in vivo and in vitro models. Animal survival, clonogenic cell survival, and tumor growth delay provide means to measure the effectiveness of treatment modalities in this tumor model. Monolayer cultures, multicellular spheroid cultures, brain tumors, and flank tumors have been used to study the influence of different biological entities of the 9L model on the response to treatment with radiation and/or BCNU (1,3-bis (2-chloroethyl)-1-nitrosourea).
19 references, click to expand
-
Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity.Int J Radiat Oncol Biol Phys. 1979 Jan;5(1):85-91 PMID: 422420
-
Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.Cancer Res. 1963 Jun;23:725-33 PMID: 13976561
-
Development of a 9L rat brain tumor cell multicellular spheroid system and its response to 1,3-bis(2-chloroethyl)-1-nitrosourea and radiation.J Natl Cancer Inst. 1980 Jun;64(6):1373-82 PMID: 6929376
-
Comparison of in vitro methods to determine drug-induced cell lethality.Cancer Res. 1976 Jul;36(7 PT 1):2182-8 PMID: 1277123
-
Is cell survival a determinant of the in situ response of 9L tumours?Br J Cancer Suppl. 1980 Apr;4:299-303 PMID: 6932940
-
In vivo clonogenic tumor cell kinetics following 1,3-bis(2-chloroethyl)-1-nitrosourea brain tumor therapy.Cancer Res. 1976 Oct;36(10):3718-25 PMID: 953998
-
Development of an in vitro colony formation assay for the evaluation of in vivo chemotherapy of a rat brain tumor.In Vitro. 1975 Sep-Oct;11(5):264-73 PMID: 1184035
-
BCNU and X-ray therapy of intracerebral 9L rat tumors.Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1581-3 PMID: 536266
-
Experimental evaluation of potential anticancer agents. VI. Anatomical distribution of leukemic cells and failure of chemotherapy.Cancer Res. 1961 Oct;21:1154-64 PMID: 13913645
-
BCNU-modification of the in vitro radiation response in 9L brain tumor cells of rats.Int J Radiat Oncol Biol Phys. 1977 Jan-Feb;2(1-2):79-88 PMID: 849907
-
Brain-tumor therapy. Quantitative analysis using a model system.J Neurosurg. 1977 Feb;46(2):145-54 PMID: 833632
-
Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea.Cancer Res. 1973 May;33(5):976-86 PMID: 4703128
-
Experimental evaluation of potential anticancer agents. XXI. Scheduling of arabinosylcytosine to take advantage of its S-phase specificity against leukemia cells.Cancer Chemother Rep. 1967 Jun;51(3):125-65 PMID: 6043735
-
Response of mammalian cells following treatment with bleomycin and 1,3-bis(2-chloroethyl)-1-nitrosourea during plateau phase.Cancer Res. 1973 Apr;33(4):691-4 PMID: 4121282
-
Radiation response of multicell spheroids--an in vitro tumour model.Curr Top Radiat Res Q. 1976 Jan;11(1):87-139 PMID: 128440
-
Isobologram analysis of X-ray--BCNU interactions in vitro.Radiat Res. 1979 Sep;79(3):483-91 PMID: 482609
-
In vivo-in vitro tumor systems: new models for studing the response of tumours to therapy.Lab Anim Sci. 1977 Oct;27(5 Pt 2):831-51 PMID: 338981
-
Morphological and immunochemical studies of rat glial tumors and clonal strains propagated in culture.J Neurosurg. 1971 Mar;34(3):310-23 PMID: 4323142
-
Cellular radiosensitivity of a rat brain tumor.Cancer. 1975 Jun;35(6):1545-50 PMID: 1148988
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