Production of anti-self H-2 antibodies by hybrid mice immune to a viral tumour.

Nature ·Vol. 289 ·No. 5798 ·1981-02-12 ·Pages 563-8

Risser R, Grunwald DJ

Abstract

During the course of immunization of hybrid mice (genotype H-2b/k) with a parental Abelson virus-induced lymphoma (genotype H-2b/b), antibodies were produced to the H-2Kb or H-2Db antigens of the immunizing cells. Such 'anti-self H-2' antibodies demonstrate the existence of autoreactive B-cell clones in hybrid mice, and pose intriguing questions for the nature of self-tolerance.

MeSH Terms

Abelson murine leukemia virus/immunology Animals Autoantibodies/biosynthesis Epitopes H-2 Antigens Immune Tolerance Immunization Leukemia Virus, Murine/immunology Leukemia, Experimental/immunology Lymphoma/immunology Mice Neoplasm Transplantation Spleen/immunology

Chemicals

Autoantibodies Epitopes H-2 Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Risser R

Grunwald D J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/289563a0

Published

1981-02-12

Pages

563-8

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/289563a0 View journal details

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Production of anti-self H-2 antibodies by hybrid mice immune to a viral tumour.

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