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PMID: 6162715 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Translational coupling during expression of the tryptophan operon of Escherichia coli.

Genetics ·Vol. 95 ·No. 4 ·1980-08-00 ·Pages 785-95

Oppenheim DS, Yanofsky C

Abstract

E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.

MeSH Terms
Escherichia coli/genetics Genes Mutation Operon Protein Biosynthesis RNA, Bacterial/genetics RNA, Messenger/genetics Tryptophan/genetics
Chemicals
RNA, Bacterial RNA, Messenger Tryptophan
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oppenheim D S
Yanofsky C
References (11)
11 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/95.4.785
Published
1980-08-00
Pages
785-95
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1214269
Subset
IM
Grants
NIGMS NIH HHS · GM-09738 · United States
External Links
PubMed source DOI: 10.1093/genetics/95.4.785 PMC Full Text View journal details
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