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PMID: 6165219 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Shared antigenic determinants between brain and thymus-derived lymphocytes in dogs.

Acta neuropathologica ·Vol. 54 ·No. 1 ·1981-00-00 ·Pages 75-82

Krakowka S, Wallace AL, Koestner A

Abstract

Canine anti-canine myelin, canine distemper convalescent, and control sera were tested for the presence of antilymphocyte antibodies in a complement-dependent microcytotoxicity assay. Sera were cytotoxic for CT 45-S cells, a canine origin thymic lymphoma, canine thymocytes, and phytomitogen-transformed canine peripheral blood lymphocytes. The cytotoxic effect was removed by absorption with canine white matter but not by absorption with galactocerebroside. The data suggests that the specificity of antimyelin and antilymphocyte antibodies is directed toward a common antigen (canine Thy-1). It is likely that, in canine distemper, these antibodies are produced following the lymphotropic phase of viral infection. The possibility that similar autoimmune phenomena observed in multiple sclerosis patients occur via an unrecognized infectious event in lymphoid tissues is raised.

MeSH Terms
Animals Antibodies/analysis Brain/immunology Demyelinating Diseases/immunology Distemper Virus, Canine/immunology Dogs Epitopes Galactosylceramides Myelin Proteins/immunology T-Lymphocytes/immunology
Chemicals
Antibodies Epitopes Galactosylceramides Myelin Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Krakowka S
Wallace A L
Koestner A
References (35)
35 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00691334
Published
1981-00-00
Pages
75-82
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
Grants
PHS HHS · 2 ROI A109022 · United States
External Links
PubMed source DOI: 10.1007/BF00691334 View journal details
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