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PMID: 6169849 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunological characterization of a low oncogenic mouse mammary tumor virus BALB/cNIV mice.

Journal of virology ·Vol. 40 ·No. 1 ·1981-10-00 ·Pages 56-64

Vacquier JP, Cardiff RD, Blair PB

Abstract

Antigenic determinants of mouse mammary tumor virus (MuMTV) from the low-mammary-tumor-incidence strain BALB/cNIV were compared by competition radioimmunoassay with those of MuMTV's isolated from several high- and low-mammary-tumor-incidence mouse strains, using rabbit hyperimmune sera against BALB/cNIV MuMTV and against MuMTV from the high-mammary-tumor-incidence strain BALB/cfC3H. Using anti-BALB/cfC3H serum in competition radioimmunoassay, BALB/cNIV MuMTV lacked antigenic determinants present on MuMTV's from the BALB/cfC3H, C3H, and GR strains. With anti-BALB/cNIV serum in competition radioimmunoassay, type-specific antigenicity was detected with BALB/cNIV MuMTV. We found class-specific antigenicities on BALB/cNIV MuMTV that were shared with RIII and C3Hf MuMTV's BALB/cNIV MuMTV was reportedly derived from the C3Hf strain by infection of BALB/c mouse mammary tissue after transplantation into a (BALB/c X C3Hf)F1 hybrid followed by retransplantation into the BALB/c strain (D. R. Pitelka, K. B. DeOme, and H. A. Bern. Proc. Am Assoc. Cancer Res. 6:51, 1965). However, BALB/cNIV MuMTV contained type-specific antigens not present on C3Hf MuMTV. The possible origin of these determinants is discussed.

MeSH Terms
Animals Antibodies, Neoplasm Antibodies, Viral Dose-Response Relationship, Immunologic Epitopes Female Mammary Neoplasms, Experimental/microbiology Mammary Tumor Virus, Mouse/immunology,pathogenicity Mice Radioimmunoassay
Chemicals
Antibodies, Neoplasm Antibodies, Viral Epitopes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vacquier J P
Cardiff R D
Blair P B
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26 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.40.1.56-64.1981
Published
1981-10-00
Pages
56-64
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256595
Subset
IM
Grants
PHS HHS · 05245 · United States
NCI NIH HHS · N01-CP-61013 · United States
External Links
PubMed source DOI: 10.1128/JVI.40.1.56-64.1981 PMC Full Text View journal details
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