The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats.
The development of bleomycin-induced pulmonary fibrosis was studied in rats depleted of neutrophils for 1 week and in rats depleted of complement for 1 week. Lung injury was assessed by histologic evaluation and by the biochemical measurement of total lung collagen. Qualitatively, histologic evidence of damage induced by bleomycin showed that damage progressed in a similar manner in neutropenic and complement-depleted animals when compared with normal animals. However, analysis of total lung collagen at 1 week after bleomycin administration revealed that collagen deposition was increased in neutropenic animals and decreased in animals depleted of complement when compared with untreated animals that received bleomycin. There were no significant differences in lung collagen levels at 1 month after bleomycin treatment in neutrophil-depleted or complement-depleted animals when compared with animals that received bleomycin alone.
17 references, click to expand
-
The phlogistic role of C3 leukotactic fragments in myocardial infarcts of rats.J Exp Med. 1971 Apr 1;133(4):885-900 PMID: 4993831
-
Stimulants of cellular proliferation in wounds.Arch Surg. 1971 Aug;103(2):167-74 PMID: 5562805
-
The neutrophilic leukocyte in wound repair a study with antineutrophil serum.J Clin Invest. 1972 Aug;51(8):2009-23 PMID: 5054460
-
The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.Am J Pathol. 1974 Nov;77(2):185-97 PMID: 4141224
-
Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis.J Clin Invest. 1977 Jan;59(1):165-75 PMID: 830661
-
Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes.J Clin Invest. 1977 Feb;59(2):273-81 PMID: 401834
-
Granulocyte collagenase: selective digestion of type I relative to type III collagen.Proc Natl Acad Sci U S A. 1977 Mar;74(3):897-901 PMID: 191839
-
Immunologic reactivity of the lung: the in vivo and in vitro generation of a neutrophil chemotactic factor by alveolar macrophages.Am Rev Respir Dis. 1978 Jan;117(1):15-23 PMID: 619716
-
Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Lung volumes, volume-pressure relations, carbon monoxide uptake, and arterial blood gas studied.Am Rev Respir Dis. 1978 Feb;117(2):289-97 PMID: 76453
-
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.Am J Pathol. 1979 Apr;95(1):117-30 PMID: 86304
-
Collagenase in the lower respiratory tract of patients with idiopathic pulmonary fibrosis.N Engl J Med. 1979 Oct 4;301(14):737-42 PMID: 225666
-
Bleomycin-induced pulmonary fibrosis in rats: biochemical demonstration of increased rate of collagen synthesis.Am Rev Respir Dis. 1980 Mar;121(3):501-6 PMID: 6158281
-
Alveolar macrophage lipoxygenase products of arachidonic acid: isolation and recognition as the predominant constituents of the neutrophil chemotactic activity elaborated by alveolar macrophages.Cell Immunol. 1980 Sep 1;54(2):390-401 PMID: 6774816
-
A clinical and experimental study of the function of neutrophils in the inflammatory response.Am J Pathol. 1958 Jul-Aug;34(4):645-69 PMID: 13559398
-
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.Arch Biochem Biophys. 1961 May;93:440-7 PMID: 13786180
-
BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS.J Exp Med. 1965 Feb 1;121:215-34 PMID: 14264268
-
A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS.J Exp Med. 1965 Jul 1;122:99-116 PMID: 14330416
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
