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PMID: 6170988 Published · ppublish English Journal Article

Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 9 ·1981-09-00 ·Pages 5895-8

Goedert M, Stoeckel K, Otten U

Abstract

Nerve growth factor is retrogradely transported in sympathetic and sensory neurons throughout life. Although this transport is known to be biologically significant in sympathetic neurons, such a function was not yet known in sensory ganglia. By using the neuropeptide substance P as a biochemical marker, we show that sensory ganglia from newborn and adult rats respond in nerve growth factor and that its retrograde axonal transport is biologically relevant, as indicated by an increase in substance P and in general protein content.

MeSH Terms
Animals Axonal Transport Axons/physiology Ganglia, Spinal/growth & development,metabolism Nerve Growth Factors/metabolism,pharmacology Radioimmunoassay Rats Rats, Inbred Strains Substance P/metabolism
Chemicals
Nerve Growth Factors Substance P
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Goedert M
Stoeckel K
Otten U
References (35)
35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.9.5895
Published
1981-09-00
Pages
5895-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348900
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.9.5895 PMC Full Text View journal details
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