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PMID: 6172384 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Production of antitoxins to two toxins of Clostridium difficile and immunological comparison of the toxins by cross-neutralization studies.

Infection and immunity ·Vol. 35 ·No. 1 ·1982-01-00 ·Pages 374-6

Libby JM, Wilkins TD

Abstract

We prepared antitoxins specific for each of two toxins of Clostridium difficile and used these to demonstrate that the toxins are immunologically distinct.

MeSH Terms
Animals Antitoxins/immunology Bacterial Toxins/immunology,toxicity Clostridium Cross Reactions Epitopes Immunization, Passive Male Mice Neutralization Tests
Chemicals
Antitoxins Bacterial Toxins Epitopes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Libby J M
Wilkins T D
References (13)
13 references, click to expand
  1. Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients.
    Infect Immun. 1978 May;20(2):526-9 PMID: 669810
  2. Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxin.
    Gastroenterology. 1979 Feb;76(2):351-5 PMID: 759263
  3. Diarrhea and colitis associated with antimicrobial therapy in man and animals.
    Am J Clin Nutr. 1979 Jan;32(1):251-7 PMID: 367148
  4. Purification and characterization of Clostridium difficile toxin.
    Infect Immun. 1979 Jul;25(1):191-201 PMID: 478634
  5. Effects of Clostridium difficile toxin on tissue-cultured cells.
    J Infect Dis. 1980 Feb;141(2):218-22 PMID: 6245152
  6. Colitis induced by Clostridium difficile.
    Rev Infect Dis. 1979 Mar-Apr;1(2):370-8 PMID: 549188
  7. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.
    J Infect Dis. 1977 Nov;136(5):701-5 PMID: 915343
  8. Production of Clostridium difficile antitoxin.
    Infect Immun. 1980 Jun;28(3):1041-3 PMID: 7399686
  9. Mucosal damage mediated by clostridial toxin in experimental clindamycin-associated colitis.
    Gut. 1980 Jun;21(6):493-9 PMID: 6776012
  10. Clinical and laboratory observations in Clostridium difficile colitis.
    Am J Clin Nutr. 1980 Nov;33(11 Suppl):2521-6 PMID: 7435423
  11. Epidemiology of experimental enterocecitis due to Clostridium difficile.
    J Infect Dis. 1980 Sep;142(3):408-13 PMID: 7441010
  12. Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis.
    J Infect Dis. 1981 Jan;143(1):42-50 PMID: 7217711
  13. Partial purification and characterization of a cytotoxin from Clostridium difficile.
    Rev Infect Dis. 1979 Mar-Apr;1(2):379-85 PMID: 549189
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.35.1.374-376.1982
Published
1982-01-00
Pages
374-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC351042
Subset
IM
Grants
NIAID NIH HHS · AI15749 · United States
External Links
PubMed source DOI: 10.1128/iai.35.1.374-376.1982 PMC Full Text View journal details
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