Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.

Nature ·Vol. 295 ·No. 5846 ·1982-01-21 ·Pages 206-8

Gubler U, Seeburg P, Hoffman BJ, Gage LP, Udenfriend S

Abstract

Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processing signals for release of each of the different components.

MeSH Terms

Adrenal Medulla/metabolism Amino Acid Sequence Animals Base Sequence Cattle Cloning, Molecular Endorphins/genetics Enkephalins/genetics Poly A/genetics Protein Biosynthesis Protein Precursors/genetics RNA/genetics RNA, Messenger/genetics Transcription, Genetic

Chemicals

Endorphins Enkephalins Protein Precursors RNA, Messenger proenkephalin Poly A RNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Gubler U

Seeburg P

Hoffman B J

Gage L P

Udenfriend S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/295206a0

Published

1982-01-21

Pages

206-8

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

J00005

External Links

PubMed source DOI: 10.1038/295206a0 View journal details

Analysis Services

Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.

Contact

WeChat Official Account