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PMID: 6182945 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Axonal and transneuronal transport of wheat germ agglutinin demonstrated by immunocytochemistry.

Brain research ·Vol. 249 ·No. 2 ·1982-10-14 ·Pages 237-46

Ruda M, Coulter JD

Abstract

Immunocytochemical methods at the light and electron microscopic level were used to examine the anterograde and retrograde transport of wheat germ agglutinin. Following anterograde transport to sensory nerve terminals in the central nervous system, wheat germ agglutinin can be localized to neuronal cell bodies in the area of terminal labeling. The transneuronal transport of wheat germ agglutinin demonstrates the existence of a mechanism whereby axonally transported glycomacromolecules might exert neurotrophic effects on postsynaptic cells.

MeSH Terms

Animals Axonal Transport Dominance, Cerebral/physiology Facial Nerve/metabolism Ganglia, Spinal/metabolism Immunoenzyme Techniques Lectins/metabolism Mechanoreceptors/metabolism Motor Neurons/metabolism Neurons/metabolism Rats Retinal Ganglion Cells/metabolism Superior Colliculi/metabolism Synapses/metabolism Synaptic Vesicles/metabolism Trigeminal Nerve/metabolism Trigeminal Nucleus, Spinal/metabolism Visual Pathways/metabolism Wheat Germ Agglutinins

Chemicals

Lectins Wheat Germ Agglutinins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ruda M

Coulter J D

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/0006-8993(82)90057-9

Published

1982-10-14

Pages

237-46

Language

English

Region

Netherlands

NLM ID

0045503

Subset

Grants

NINDS NIH HHS · NS11255 · United States

NINDS NIH HHS · NS12481 · United States

External Links

PubMed source DOI: 10.1016/0006-8993(82)90057-9 View journal details

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Axonal and transneuronal transport of wheat germ agglutinin demonstrated by immunocytochemistry.

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