Vasoactive peptides. State-of-the-art review.

Hypertension (Dallas, Tex. : 1979) ·Vol. 5 ·No. 2 Pt 2 ·1983-00-00 ·Pages I17-26

Said SI

Abstract

At least 16 naturally occurring peptides either constrict or dilate blood vessels. Many of these peptides are present in nerve cells and nerve terminals supplying systemic and pulmonary blood vessels and the heart. Such neuropeptides are released locally as neurotransmitters, and can influence vascular tone, local and regional blood flow, arterial blood pressure, and cardiac function. There is evidence for the participation of at least some vasoactive peptides in the regulation of these functions and in the mediation or modulation of systemic shock and arterial hypertension. The investigation of vasoactive peptides in relation to cardiovascular function and dysfunction is at a promising threshold.

MeSH Terms

Angiotensin II/physiology Animals Bombesin/metabolism Bradykinin/physiology Cardiovascular Physiological Phenomena Cholecystokinin/physiology Endorphins/physiology Humans Hypertension/physiopathology Myocardium/metabolism Neurotensin/physiology Neurotransmitter Agents/physiology Oxytocin/physiology Parathyroid Hormone/physiology Peptides/physiology Prolactin/physiology Pulmonary Circulation Shock/physiopathology Somatostatin/physiology Substance P/physiology Thyrotropin-Releasing Hormone/physiology Tissue Distribution Urotensins/physiology Vasoactive Intestinal Peptide/physiology Vasoconstriction Vasodilation Vasopressins/physiology

Chemicals

Endorphins Neurotransmitter Agents Parathyroid Hormone Peptides Urotensins Vasopressins Angiotensin II Substance P Vasoactive Intestinal Peptide Neurotensin Oxytocin Somatostatin Thyrotropin-Releasing Hormone Prolactin Cholecystokinin urotensin I Bombesin Bradykinin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Said S I

Article Info

Journal

Hypertension (Dallas, Tex. : 1979)

Abbr.

Hypertension

ISSN

0194-911X

DOI

10.1161/01.hyp.5.2_pt_2.i17

Published

1983-00-00

Pages

I17-26

Language

English

Region

United States

NLM ID

7906255

Subset

External Links

PubMed source DOI: 10.1161/01.hyp.5.2_pt_2.i17 View journal details

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