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PMID: 6186650 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Peptide-containing innervation of the human intestinal mucosa. An immunocytochemical study on whole-mount preparations.

Histochemistry ·Vol. 76 ·No. 3 ·1982-00-00 ·Pages 413-20

Ferri GL, Botti PL, Vezzadini P, Biliotti G, Bloom SR, Polak JM

Abstract

The three-dimensional distribution of the peptide-containing innervation in the human intestinal mucosa was studied by fluorescence immunohistochemistry on whole-mount mucosal preparations. An extensive VIP-immunoreactive nerve supply was demonstrated at all levels, but was markedly increased in density in the distal intestine, where it formed a particularly rich network in close contact with the luminal epithelium. In contrast, substance P-containing nerve fibres formed a looser and evenly distributed innervation at all levels. The muscularis mucosae was richly supplied by VIP- and substance P-containing fibres. Met-enkephalin immunoreactivity was confined to a few scattered nerve bundles running in the muscularis mucosae and around the bottom of epithelial crypts.

MeSH Terms
Animals Enkephalin, Methionine/analysis Histocytochemistry/methods Humans Immunochemistry/methods Intestinal Mucosa/analysis,innervation Peptides/analysis Substance P/analysis Swine/immunology Vasoactive Intestinal Peptide/analysis
Chemicals
Peptides Substance P Vasoactive Intestinal Peptide Enkephalin, Methionine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ferri G L
Botti P L
Vezzadini P
Biliotti G
Bloom S R
Polak J M
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18 references, click to expand
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Article Info
Journal
Histochemistry
Abbr.
Histochemistry
ISSN
0301-5564
DOI
10.1007/BF00543961
Published
1982-00-00
Pages
413-20
Language
English
Region
Germany
NLM ID
0411300
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00543961
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