Home LiteratureArticle Details
PMID: 6197359 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

T cell proliferation in Mycobacterium lepraemurium infection. I. Lack of correlation between antigen-specific proliferation of Lyt 1 + 23- cells and resistance in lethal infections.

Immunology ·Vol. 51 ·No. 1 ·1984-01-00 ·Pages 185-92

Mathew RC, Curtis J, Turk JL

Abstract

Antigen specific T lymphocyte proliferation and Lyt phenotypes of the T lymphocytes were studied in BALB/c and C57BL/6 mice infected with 10(9) M. lepraemurium organisms intravenously. A highly disseminated form of the disease developed to which all mice succumbed by 17 weeks. Maximal antigen-specific T lymphocyte proliferation was detected at 4 weeks after the infection and persisted thereafter even when the mice started to die of the infection. Accessory cells of phagocytic and adherent type did not appear to be a requirement for this proliferation. The T lymphocytes generated during the course of the infection were mostly of the Lyt 1 phenotype. However, there appeared to be no correlation between sensitized Lyt 1 cells capable of antigen-induced T lymphocyte proliferation and protective immunity.

MeSH Terms
Animals Antigens, Bacterial/immunology Cell Division Epitopes Female Immunity, Innate Immunization, Passive Leukocyte Count Liver/pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium Infections/immunology,pathology Mycobacterium lepraemurium Spleen/pathology T-Lymphocytes/immunology
Chemicals
Antigens, Bacterial Epitopes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mathew R C
Curtis J
Turk J L
References (29)
29 references, click to expand
  1. Antigen specific lymphocyte transformation, delayed hypersensitivity and protective immunity. I. Kinetics of the response.
    Cell Immunol. 1978 May;37(2):315-26 PMID: 566166
  2. Deficit of interleukin 2 production associated with impaired T-cell proliferative responses in Mycobacterium lepraemurium infection.
    Infect Immun. 1983 Jan;39(1):109-16 PMID: 6337092
  3. Experimental lepromatous leprosy.
    Nature. 1967 Aug 5;215(5101):599-602 PMID: 4860661
  4. Enhancing effect of antilymphocytic globulin on human leprosy infection in thymectomized mice.
    Nature. 1968 Dec 21;220(5173):1246-8 PMID: 4881925
  5. The host response to Calmette-Guérin bacillus infection in mice.
    J Exp Med. 1969 May 1;129(5):1079-107 PMID: 4976109
  6. Granuloma formation in lymph nodes.
    Proc R Soc Med. 1971 Sep;64(9):942-4 PMID: 5114300
  7. The walls of Mycobacterium lepraemurium: chemistry and ultrastructure.
    J Gen Microbiol. 1971 Dec;69(3):313-24 PMID: 4335581
  8. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy.
    Clin Exp Immunol. 1973 Aug;14(4):541-53 PMID: 4583777
  9. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.
    J Exp Med. 1975 Jun 1;141(6):1376-89 PMID: 1092798
  10. Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses.
    J Exp Med. 1976 Jun 1;143(6):1534-9 PMID: 1083891
  11. Lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions.
    Clin Exp Immunol. 1976 Jul;25(1):85-94 PMID: 791549
  12. The spectrum of human tuberculosis.
    Clin Exp Immunol. 1977 Feb;27(2):230-7 PMID: 849655
  13. An in vitro assay for the quantitation of phagocytic cells of different anatomic origin.
    Acta Pathol Microbiol Scand C. 1977 Aug;85C(4):253-9 PMID: 70958
  14. The expression of Ia antigens on immunocompetent cells in the guinea pig. II. Ia antigens on macrophages.
    J Immunol. 1977 Nov;119(5):1584-8 PMID: 144161
  15. Trypanosoma cruzi: in vitro induction of macrophage microbicidal activity.
    J Exp Med. 1978 Jul 1;148(1):288-300 PMID: 353218
  16. Development of delayed hypersensitivity responses in Mycobacterium lepraemurium infections in resistant and susceptible strains of mice.
    Immunology. 1979 Mar;36(3):563-7 PMID: 374255
  17. Lepromin-induced suppressor cells in patients with leprosy.
    J Immunol. 1979 Oct;123(4):1813-7 PMID: 158056
  18. Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens.
    J Exp Med. 1979 Oct 1;150(4):1033-8 PMID: 117073
  19. Studies on immune response to Mycobacterium lepraemurium. Evaluation of the cell-mediated immune response in mice.
    Int Arch Allergy Appl Immunol. 1980;62(4):423-32 PMID: 6991443
  20. Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor.
    J Exp Med. 1980 Jun 1;151(6):1398-412 PMID: 6155422
  21. Influence of route of Mycobacterium lepraemurium injection on susceptibility to mouse leprosy and on lymphoblastic transformation.
    Infect Immun. 1980 Jun;28(3):660-8 PMID: 6995320
  22. Development of suppressor T cells in mice heavily infected with mycobacteria.
    Immunology. 1980 Mar;39(3):367-73 PMID: 6449470
  23. Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.
    Clin Exp Immunol. 1980 Nov;42(2):203-10 PMID: 6451335
  24. Modulation of granulomatous hypersensitivity. II. Participation of Ly 1+ and Ly 2+ T lymphocytes in the suppression of granuloma formation and lymphokine production in Schistosoma mansoni-infected mice.
    J Immunol. 1981 Jul;127(1):363-7 PMID: 6972410
  25. The specificity of suppressor T cells induced by chronic Mycobacterium avium infection in mice.
    Clin Exp Immunol. 1981 Jan;43(1):10-9 PMID: 6454515
  26. Immunologic regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells.
    J Immunol. 1982 Apr;128(4):1917-22 PMID: 6120976
  27. Differences in cell-mediated immune responses of 'high-resistance' and 'low-resistance' mice to a nonpathogenic mycobacterium.
    Scand J Immunol. 1981 Nov;14(5):467-80 PMID: 7038853
  28. Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity/Lsh pattern.
    Immunology. 1982 Sep;47(1):149-56 PMID: 6749659
  29. Effective antibacterial protection induced by a Listeria monocytogenes-specific T cell clone and its lymphokines.
    Infect Immun. 1983 Mar;39(3):1265-70 PMID: 6220971
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1984-01-00
Pages
185-92
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1454396
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2