Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.

British journal of cancer ·Vol. 37 ·No. 1 ·1978-01-00 ·Pages 81-5

Bellamy D, Hinsull SM

Abstract

The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.c. tumour. In addition, host lung tissue was found to inhibit the development of metastases, and it is postulated that the host tissue may produce a diffusible inhibitor and that differences in the effectiveness of these humoral factors may account, in part, for locational differences in tumour growth patterns.

MeSH Terms

Animals Carcinoma 256, Walker/pathology Cell Count Injections, Intravenous Injections, Subcutaneous Lung Neoplasms/pathology Male Mitotic Index Neoplasm Metastasis Neoplasm Transplantation/methods Rats Rats, Inbred Strains Time Factors Transplantation, Homologous

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bellamy D

Hinsull S M

References (12)

12 references, click to expand

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1978.12

Published

1978-01-00

Pages

81-5

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2009512

Subset

External Links

PubMed source DOI: 10.1038/bjc.1978.12 PMC Full Text View journal details

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Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.

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