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PMID: 62011 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Ly phenotype of cytotoxic T cells for syngeneic tumor.

The Journal of experimental medicine ·Vol. 144 ·No. 4 ·1976-10-01 ·Pages 1116-20

Shiku H, Takahashi T, Bean MA, Old LJ, Oettgen HF

Abstract

Our present and previous findings may be summarized as follows: The phenotype of C57BL/6 (B6) cytotoxic cells for allogeneic target cells is Thy-1+, Ly-1- Ly-2/3+, MSLA+, and Ig-. the phenotype of B6 cytotoxic cells for syngeneic tumor cells is Thy-1+, Ly-1+, Ly-2/3+, MSLA+, and Ig-. The phenotype of B6 cytotoxic cells for syngeneic tumor cells is Thy-1+, Ly-1+, Ly-2/3+, MSLA+, AND Ig-. Thus, differences in Ly phenotype appear to be exhibited not only by cytotoxic T cells as opposed to helper T cells, but also within subcategories of cytotoxic T cells.

MeSH Terms
Animals Cytotoxicity Tests, Immunologic Epitopes Female Mice Mice, Inbred C57BL Neoplasm Transplantation Neoplasms, Experimental Phenotype Sarcoma/immunology T-Lymphocytes/immunology Transplantation, Isogeneic
Chemicals
Epitopes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Shiku H
Takahashi T
Bean M A
Old L J
Oettgen H F
References (5)
5 references, click to expand
  1. Expression of T-cell differentiation antigens on effector cells in cell-mediated cytotoxicity in vitro. Evidence for functional heterogeneity related to the surface phenotype of T cells.
    J Exp Med. 1975 Jan 1;141(1):227-41 PMID: 1078839
  2. Surface phenotype of nonadherent peritoneal cells effecting cell-mediated cytotoxicity in vitro for allogeneic and syngeneic murine sarcoma cells.
    Isr J Med Sci. 1976 Apr-May;12(4-5):425-34 PMID: 1084882
  3. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse.
    Nature. 1975 Jan 17;253(5488):219-20 PMID: 234178
  4. Cytotoxic reactions of murine lymphoid cells studied with a tritiated proline microcytotoxicity test.
    J Natl Cancer Inst. 1975 Feb;54(2):415-25 PMID: 1113324
  5. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.
    J Exp Med. 1975 Jun 1;141(6):1376-89 PMID: 1092798
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.144.4.1116
Published
1976-10-01
Pages
1116-20
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190425
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.144.4.1116 PMC Full Text View journal details
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