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PMID: 6201866 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The structure of bovine brain myelin proteolipid and its organization in myelin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 9 ·1984-05-00 ·Pages 2912-6

Laursen RA, Samiullah M, Lees MB

Abstract

A model, based on amino acid sequence data, is proposed for the organization of the myelin proteolipid in myelin membrane. The model has three distinctive features: three trans-membrane segments that traverse the lipid bilayer, two cis-membrane domains that enter and exit the same side of the membrane, and a highly charged segment resembling myelin basic protein on the cytoplasmic side of the membrane. It is proposed that the cis-membrane domain(s) can promote the formation and stabilization of the multilamellar myelin structure by hydrophobic interaction with the apposite bilayer across the extracellular space.

MeSH Terms
Amino Acid Sequence Animals Cattle Cysteine Myelin Proteins/biosynthesis Myelin Proteolipid Protein Myelin Sheath/ultrastructure Protein Conformation Proteolipids Solubility Structure-Activity Relationship Water
Chemicals
Myelin Proteins Myelin Proteolipid Protein Proteolipids Water Cysteine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Laursen R A
Samiullah M
Lees M B
References (23)
23 references, click to expand
  1. Carboxymethylation of sulphydryl groups in proteolipids.
    J Neurochem. 1969 Jun;16(3):1025-32 PMID: 5822626
  2. The amino-acid sequence x-ray methods, and its correlation with chemical data.
    Nature. 1961 May 20;190:666-70 PMID: 13752474
  3. Structural organization of the human myelin membrane.
    Biochim Biophys Acta. 1978 Apr 10;515(1):1-21 PMID: 76479
  4. Prediction of chain turns in globular proteins on a hydrophobic basis.
    Nature. 1978 Apr 13;272(5654):586-90 PMID: 643051
  5. Tryptic peptides from bovine white matter proteolipids.
    J Neurochem. 1978 May;30(5):983-90 PMID: 660200
  6. Three-dimensional structure and disulfide bond connections in bovine pancreatic phospholipase A2.
    J Mol Biol. 1978 Sep 5;124(1):53-60 PMID: 712836
  7. Prediction of the secondary structure of proteins from their amino acid sequence.
    Adv Enzymol Relat Areas Mol Biol. 1978;47:45-148 PMID: 364941
  8. Structural studies of the apoprotein of the Folch-Pi bovine brain myelin proteolipid : characterization of the CNBr-fragments and of a long C-terminal sequence.
    Biochem Biophys Res Commun. 1979 Mar 30;87(2):619-26 PMID: 444242
  9. Structure and function of proteolipids in myelin and non-myelin membranes.
    Biochim Biophys Acta. 1979 Aug 20;559(2-3):209-30 PMID: 157777
  10. Path of the polypeptide in bacteriorhodopsin.
    Proc Natl Acad Sci U S A. 1980 Apr;77(4):2023-7 PMID: 6929535
  11. The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis.
    Cell. 1981 Feb;23(2):411-22 PMID: 7471207
  12. Orientation of the carboxyl and NH2 termini of the membrane-binding segment of cytochrome b5 on the same side of phospholipid bilayers.
    J Biol Chem. 1981 Apr 25;256(8):3951-5 PMID: 7217066
  13. The anatomy and taxonomy of protein structure.
    Adv Protein Chem. 1981;34:167-339 PMID: 7020376
  14. Prediction of the secondary structure of myelin basic protein.
    J Neurochem. 1981 Apr;36(4):1543-60 PMID: 6167675
  15. Charge clusters and the orientation of membrane proteins.
    J Membr Biol. 1982;66(3):203-12 PMID: 6808138
  16. A simple method for displaying the hydropathic character of a protein.
    J Mol Biol. 1982 May 5;157(1):105-32 PMID: 7108955
  17. Structural prediction of membrane-bound proteins.
    Eur J Biochem. 1982 Nov 15;128(2-3):565-75 PMID: 7151796
  18. Enzymic and chemical fragmentation of the apoprotein of the major rat brain myelin proteolipid.
    Biochim Biophys Acta. 1983 Jan 12;742(1):33-8 PMID: 6337633
  19. Interior turns in globular proteins.
    Nature. 1983 Aug 18-24;304(5927):654-7 PMID: 6877386
  20. Gene duplication in bovine brain myelin proteolipid and homology with related proteins.
    FEBS Lett. 1983 Sep 5;161(1):71-4 PMID: 6884530
  21. Amino acid sequence of bovine white matter proteolipid.
    Arch Biochem Biophys. 1983 Oct 15;226(2):643-56 PMID: 6195969
  22. The primary structure of bovine brain myelin lipophilin (proteolipid apoprotein).
    Hoppe Seylers Z Physiol Chem. 1983 Oct;364(10):1455-66 PMID: 6642431
  23. Myelin membrane structure at 10 A resolution.
    Nat New Biol. 1971 May 12;231(19):46-52 PMID: 5283387
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.9.2912
Published
1984-05-00
Pages
2912-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345183
Subset
IM
Grants
NINDS NIH HHS · NS 13649 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.9.2912 PMC Full Text View journal details
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