Home LiteratureArticle Details

PMID: 6204969 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Aphidicolin inhibits growth and DNA synthesis in halophilic arachaebacteria.

Journal of bacteriology ·Vol. 159 ·No. 2 ·1984-08-00 ·Pages 800-2

Forterre P, Elie C, Kohiyama M

Abstract

Aphidicolin, a specific inhibitor of eucaryotic alpha DNA polymerase, inhibits the growth of halophilic arachaebacteria. In Halobacterium halobium, aphidicolin prevents cell division and DNA synthesis. These results suggest that arachaebacterial replicases are of the eucaryotic type.

MeSH Terms

Antiviral Agents/toxicity Aphidicolin Bacterial Proteins/biosynthesis DNA Replication/drug effects Diterpenes/toxicity Halobacterium/drug effects,growth & development Kinetics RNA, Bacterial/biosynthesis

Chemicals

Antiviral Agents Bacterial Proteins Diterpenes RNA, Bacterial Aphidicolin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Forterre P

Elie C

Kohiyama M

References (9)

9 references, click to expand

Archaebacteria and eukaryotes possess DNA-dependent RNA polymerases of a common type.
EMBO J. 1983;2(8):1291-4 PMID: 10872322
Purification and characterization of a prokaryotic glycoprotein from the cell envelope of Halobacterium salinarium.
J Biol Chem. 1976 Apr 10;251(7):2005-14 PMID: 1270419
Recent developments in the molecular biology of extremely halophilic bacteria.
CRC Crit Rev Microbiol. 1978;6(2):151-205 PMID: 365457
Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes.
J Virol. 1980 Nov;36(2):457-64 PMID: 6253671
Effect of some metal ions on the growth of Halobacterium cutirubrum.
Can J Microbiol. 1960 Apr;6:165-9 PMID: 14444586
Taxonomic relations between archaebacteria including 6 novel genera examined by cross hybridization of DNAs and 16S rRNAs.
J Mol Evol. 1982;18(2):109-14 PMID: 6178834
In vitro replication of bacteriophage phi 29 DNA.
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5245-8 PMID: 6813856
Putative introns in tRNA genes of prokaryotes.
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3309-12 PMID: 6304706
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha.
Cell. 1981 Mar;23(3):647-8 PMID: 6784928

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.159.2.800-802.1984

Published

1984-08-00

Pages

800-2

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC215722

Subset

External Links

PubMed source DOI: 10.1128/jb.159.2.800-802.1984 PMC Full Text View journal details

Analysis Services

Aphidicolin inhibits growth and DNA synthesis in halophilic arachaebacteria.

Contact

WeChat Official Account