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PMID: 62059 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Presence of murine leukemia virus envelope proteins gp70 and p15(E) in a common polyprotein of infected cells.

Journal of virology ·Vol. 20 ·No. 2 ·1976-11-00 ·Pages 501-8

Famulari NG, Buchhagen DL, Klenk HD, Fleissner E

Abstract

The murine leukemia virus envelope proteins, p15(E) and gp70, exhibit a mode of processing distinct from that of virion core proteins according to three criteria. First, the incorporation of both p15(E) and gp70 into virions is more sensitive to the metabolic analogue 2-deoxy-D-glucose than the incorporation of core proteins. Second, the kinetics with which the newly synthesized envelope proteins appear in the released virions is delayed relative to the appearance of core proteins. Third, immunoprecipitation of large polypeptides from infected cells reveals the presence of gp70 and p15(E) in a common precursor distinct from the core polyprotein.

MeSH Terms
Cell Line Deoxyglucose/pharmacology Epitopes Molecular Weight Protein Precursors/immunology,metabolism Rauscher Virus/immunology,metabolism Viral Proteins/biosynthesis,immunology,metabolism
Chemicals
Epitopes Protein Precursors Viral Proteins Deoxyglucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Famulari N G
Buchhagen D L
Klenk H D
Fleissner E
References (31)
31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.20.2.501-508.1976
Published
1976-11-00
Pages
501-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC355017
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.20.2.501-508.1976 PMC Full Text View journal details
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