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PMID: 6216479 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Distance from cohesive end site cos determines the replication requirement for recombination in phage lambda.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 20 ·1982-10-00 ·Pages 6318-21

Stahl FW, Kobayashi I, Stahl MM

Abstract

Previous work showed that crossing-over in the middle of the chromosome of phage lambda requires more DNA replication than does crossing-over near the termini. Relocation of cos, the sequence that determines the lambda termini, alters the requirements for replication in a given marked interval, demonstrating that distance from cos determines the amount of DNA replication that is required for genetic exchange. This result supports a break and copy mechanism for recombination mediated by the red system of phage lambda.

MeSH Terms
Bacterial Proteins/metabolism Bacteriophage lambda/genetics Chromosome Mapping DNA Replication DNA, Viral/biosynthesis Genes, Viral Rec A Recombinases Recombination, Genetic
Chemicals
Bacterial Proteins DNA, Viral Rec A Recombinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stahl F W
Kobayashi I
Stahl M M
References (21)
21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.20.6318
Published
1982-10-00
Pages
6318-21
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347112
Subset
IM
Grants
NIGMS NIH HHS · GM 20373 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.20.6318 PMC Full Text View journal details
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