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PMID: 621781 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of maturation of Rauscher leukemia virus by amino acid analogs.

Journal of virology ·Vol. 25 ·No. 1 ·1978-01-00 ·Pages 408-12

Jamjoom GA, Ng VL, Arlinghaus RB

Abstract

Synthesis of primary precursor polyproteins of Rauscher leukemia virus (RLV) core and envelope proteins occurs in the presence of amino acid analogs canavanine and p-fluorophenylalanine, but cleavage of these precursors is severely inhibited or slowed down. After treatment with these agents, the release of characteristic virus or stable virus-like particles is greatly depressed.

MeSH Terms
Canavanine/pharmacology Culture Techniques Peptide Biosynthesis Phenylalanine/analogs & derivatives Protein Precursors/biosynthesis,metabolism Rauscher Virus/drug effects,growth & development,metabolism Viral Proteins/biosynthesis,metabolism Virus Replication/drug effects p-Fluorophenylalanine/pharmacology
Chemicals
Protein Precursors Viral Proteins Canavanine Phenylalanine p-Fluorophenylalanine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jamjoom G A
Ng V L
Arlinghaus R B
References (21)
21 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.25.1.408-412.1978
Published
1978-01-00
Pages
408-12
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353938
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.25.1.408-412.1978 PMC Full Text View journal details
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